In vitro antimalarial activity of quassinoids from Eurycoma longifolia against Malaysian chloroquine-resistant Plasmodium falciparum isolates [letter

Author

Ang HH ; Chan KL ; Mak JW

Source

Planta Med, 61(2):177-8 1995 Apr

Abstract

Three quassinoids from the roots of Eurycoma longifolia Jack were evaluated for antimalarial activity against nine Plasmodium falciparum isolates obtained from patients infected with chloroquine-resistant malaria. The results indicated that eurycomanol, eurycomanol 2-O-beta-D-glucopyranoside, and 13 beta, 18-dihydroeurycomanol possessed antimalarial activity with IC50 values of 1.231-4.899 microM, 0.389-3.498 microM, and 0.504-2.343 microM, respectively, compared with 0.323-0.774 microM for chloroquine.

Language

Eng

Unique Identifier

95273493

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Major MeSH Headings

Antimalarials PD ; Chloroquine PD ; Glaucarubin AA ; Plants, Medicinal CH ; Plasmodium falciparum DE Minor MeSH Headings

Minor MeSH Headings

Animal ; Drug Resistance ; Glaucarubin PD ; Human

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